University of Oxford

University of Oxford

Senior Postdoctoral Research Assistant - Structural analysis of HLA-E-peptide recognition by T cell receptors

United Kingdom

Closing in 13 days

Senior Postdoctoral Research Assistant - Structural analysis of HLA-E-peptide recognition by T cell receptors

Oxford Centre for Immuno-Oncology, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ

Do you have a keen interest in therapeutic or vaccination strategies that involve the targeting of peptide epitopes restricted by HLA-E? We have a new role working at the Oxford Centre for Immuno-Oncology, working on a project aiming to elucidate how peptides loaded onto HLA-E are recognised by low affinity T cells from a structural and biophysical perspective.

You will collaboratively work alongside an existing team to support new studies centred on HLA-E peptide binding biochemistry, as well as ensuring research is performed safely, legally and to the highest possible standards. You will also establish and maintain a good understanding of the research field by reading key reviews and research articles. Additionally, you will adapt existing and develop new scientific techniques and protocols as necessary, testing hypotheses and analyse scientific data from a variety of sources, refining as required.

It is essential that you hold a PhD/DPhil in Biochemistry, Chemistry, or Biophysics working on immune proteins such as T cell receptors and major histocompatibility complex (MHC) proteins. You will understand basic molecular biology techniques including PCR, cloning, mutagenesis and sequencing, as well as protein production using prokaryotic or eukaryotic expression platforms and purification using FPLC systems. In addition, you will have experience of structural analysis of proteins using either cryoEM and/or x-ray crystallography, and biophysical analysis of protein-protein interactions using Surface Plasmon Resonance and/or Microsale Thermophoresis systems. Experience or good working knowledge of Nuclear Magnetic Resonance Spectroscopy would be highly desirable.

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

This position is offered full time on a fixed term contract until 31 August 2028 and is funded by the Wellcome Trust.

Only applications received before 12 midday on 6 March 2024 will be considered. Please quote 170970 on all correspondence.

Contact Person : Phoebe Astbury Vacancy ID : 170970 Contact Phone : 01865 287775 Closing Date & Time : 06-Mar-2024 12:00 Pay Scale : STANDARD GRADE 8 Contact Email : [email protected] Salary (£) : Grade 8: Salary in range £45,585 - £54,395 per annum

Job details

Title

Senior Postdoctoral Research Assistant - Structural analysis of HLA-E-peptide recognition by T cell receptors

Employer

University of Oxford

Location

United Kingdom

Published

February 08, 2024

Application deadline

March 06, 2024

Job type

Postdoc

Field

Agricultural Science,Biology,Chemistry,Physics

About the employer

The University of Oxford is the oldest university in the English-speaking world, and is actually so ancient that its founding date is unknown – though it is thought that teaching took place there as early as the 11th century. It’s located in and around the medieval city center of Oxford, dubbed “the dreaming city of spires” by the 19th century poet Matthew Arnold, and comprises 44 colleges and halls as well as the largest library system in the UK. 

There are 22,000 students at Oxford in total, around half of whom are undergraduates, while 40 per cent are international students. A quarter of the city of Oxford’s residents are students, giving the city the youngest population in the UK. 

The University of Oxford does not have a main campus, its buildings and facilities instead being scattered around the medieval city center. Its colleges each have a distinctive character and traditions often dating back centuries. Colleges are self-governing institutions to which students usually apply directly. There are four academic divisions within Oxford University: Humanities, Mathematical, Physical and Life Sciences; Medical Sciences; and Social Sciences. The university’s particular strength is the sciences, and it is ranked number one in the world for medicine.

Oxford is a youthful and cosmopolitan city with plenty to see and do. There are dozens of historic and iconic buildings, including the Bodleian Libraries, Ashmolean Museum, Sheldonian Theatre, the cathedral, and the colleges themselves.  Students can choose to spend their time studying or avail themselves of the many extracurricular activities available. There’s a strong musical life at Oxford, with clubs and societies spanning all genres, from jazz, through to classical and folk. Oxford is also ranked highly for sport, with its top rowers taking part every year in the world-famous boat race with the University of Cambridge on the River Thames. Drama lovers are also well catered for, with one of the largest and most vibrant university drama scenes in the country.

Oxford has an alumni network of over 250,000 individuals, including more than 120 Olympic medalists, 26 Nobel Prize winners, seven poets laureate, and over 30 modern world leaders (including Bill Clinton, Aung San Suu Kyi, Indira Ghandi and 26 UK Prime Ministers). 

It has a friendly rivalry with Cambridge for the title of best university in the UK and is regularly ranked as being one of the top three universities in the world. Notable Oxford thinkers and scientists include Tim Berners-Lee, Stephen Hawking and Richard Dawkins.

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