University of Cambridge

University of Cambridge

Research Associate - Genome regulation

United Kingdom

Closing in 5 days

Research Associate - Genome regulation

The Ahringer lab in the Gurdon Institute is looking for an experienced laboratory research scientist with expertise in molecular biology and genomics to support its research programmes. We decipher how chromatin and gene expression are regulated to direct the step-by-step development of the single- celled totipotent zygote to the differentiated state. We use the C. elegans model, where the invariant lineage makes it the only organism where it is feasible to determine cell-to-cell genomic regulatory transitions across development. We apply single cell profiling, bulk genomic assays, microscopy, and mutant analyses to determine how the genome is regulated to drive developmental decisions and their expression.

This is a key role that will offer collaborative support and technical expertise across the scientific programmes in the laboratory. The role covers a wide range of activities, allowing for continuity of lab operations. Activities include:

  • Collaborating with lab members on research projects.
  • Providing experimental or technical support to other lab members.
  • Providing technical expertise and input to develop, optimise and troubleshoot relevant and novel methodologies.
  • Independently undertaking own research projects, designing, and executing experiments in consultation with the group leader.
  • Participating in academic activities, including group meetings and journal clubs, seminars, and scientific meetings.
  • Writing up findings and completing revisions.
  • Maintaining laboratory organisation, supplies, and safety procedures
  • Training new and existing lab members in standard operating procedures
  • This is a highly collaborative position, so excellent communication and interpersonal skills are essential. You should be a motivated and organised individual with expertise in a broad range of molecular biology techniques and have the ability to work both independently and as part of a team. Experience in genomic profiling techniques (e.g. ChIP-seq, ATAC-seq, RNA-seq, single cell analyses) is highly desirable. Candidates should have a PhD in a relevant discipline and have a capacity to apply initiative and creativity to solve technical and biological problems.

    The Gurdon Institute is a world-renowned centre of Developmental biology and Cancer research embedded in the University of Cambridge. It provides an exceptional and stimulating environment that promotes collaborative and interdisciplinary research in a supportive and modern setting, with access to state-of-the-art technologies such as super-resolution imaging, single-cell analyses, genome engineering, and genomics and computer modelling.

    Informal enquiries can be made to Julie Ahringer via [email protected]

    If you have any questions about this vacancy or the application process, please contact [email protected].

    Fixed-term: The funds for this post are available until 31 December 2025 in the first instance.

    Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

    Please quote reference PR41123 on your application and in any correspondence about this vacancy.

    The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

    The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

    Further information
  • Further Particulars
  • Department/Location

    Wellcome Trust/Cancer Research UK Gurdon Institute

    Salary

    £36,024-£44,263

    Reference

    PR41123

    Category

    Research

    Published

    28 March 2024

    Closing date

    28 April 2024

    Job details

    Title

    Research Associate - Genome regulation

    Employer

    University of Cambridge

    Location

    United Kingdom

    Published

    March 29, 2024

    Application deadline

    April 28, 2024

    Job type

    Research

    Field

    Biology,Chemistry,Physics

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