Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Headington, Oxford, OX3 9DU
We are looking for an enthusiastic postdoctoral researcher looking to develop an independent research career is required for a cutting-edge program of research to systematically investigate calcium channel antagonists as a class of drugs with potential for disease modification in amyotrophic lateral sclerosis (ALS). Several members of the class of CCBs will be assessed for phenotypical modification and target engagement across a range of cellular models (an ESC-derived motor neuron model of ALS, iPSC-models based on a number of ALS determining mutations). Specifically, we aim to 1) Establish whether the effect of CCBs (for which we have preliminary evidence) is a class effect, 2) determine the specific targets of calcium channel blockers, which mediate improved survival in our cellular models, 3) in collaboration with colleagues in Edinburgh extend testing to mouse and zebrafish models. The ultimate goal is to select CCBs for prioritization in experimental medicine studies in humans with ALS and to develop drug specific biomarkers for use in these studies.
Some of your duties will include developing, establishing, and pursuing appropriate analytical protocols (cell culture, imaging, biochemical) and techniques to support research for the project and developing research questions, testing hypotheses and analysing scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. As well as supervision of graduate students, acting as a source of information and advice to other members of the group on scientific protocols and experimental techniques, liaison with collaborators and manage own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines.
It is essential that you hold or be close to award of a doctorate (PhD/DPhil) in Neuroscience, have a proven track record in cell culture (particularly iPSC and ESC-derived neuronal cell culture) and experience in molecular biology techniques.
It is desirable that you have experience of research in neurodegeneration and experience of grant applications.
Please see the below 'Job Description' for further details on the responsibilities and selection criteria, as well as further information about the university and how to apply.
The post is full time, fixed term until 27th March 2027
Only applications received before 12.00 midday on Monday 4th March will be considered.
Interviews will be held as soon as possible thereafter.
Contact Person : NDCN HR Recruitment Vacancy ID : 171060 Contact Phone : Closing Date & Time : 04-Mar-2024 12:00 Pay Scale : STANDARD GRADE 7 Contact Email : [email protected] Salary (£) : £33,309 - £40,927 per annum, A less experienced candidate may be appointed at Grade 6 (£32,332 - £38,205 per annum), with a commensurate adjustment in either the essential criteria, responsibilities or duties.
University of Oxford
February 13, 2024
March 04, 2024
About the employer
The University of Oxford is the oldest university in the English-speaking world, and is actually so ancient that its founding date is unknown – though it is thought that teaching took place there as early as the 11th century. It’s located in and around the medieval city center of Oxford, dubbed “the dreaming city of spires” by the 19th century poet Matthew Arnold, and comprises 44 colleges and halls as well as the largest library system in the UK.
There are 22,000 students at Oxford in total, around half of whom are undergraduates, while 40 per cent are international students. A quarter of the city of Oxford’s residents are students, giving the city the youngest population in the UK.
The University of Oxford does not have a main campus, its buildings and facilities instead being scattered around the medieval city center. Its colleges each have a distinctive character and traditions often dating back centuries. Colleges are self-governing institutions to which students usually apply directly. There are four academic divisions within Oxford University: Humanities, Mathematical, Physical and Life Sciences; Medical Sciences; and Social Sciences. The university’s particular strength is the sciences, and it is ranked number one in the world for medicine.
Oxford is a youthful and cosmopolitan city with plenty to see and do. There are dozens of historic and iconic buildings, including the Bodleian Libraries, Ashmolean Museum, Sheldonian Theatre, the cathedral, and the colleges themselves. Students can choose to spend their time studying or avail themselves of the many extracurricular activities available. There’s a strong musical life at Oxford, with clubs and societies spanning all genres, from jazz, through to classical and folk. Oxford is also ranked highly for sport, with its top rowers taking part every year in the world-famous boat race with the University of Cambridge on the River Thames. Drama lovers are also well catered for, with one of the largest and most vibrant university drama scenes in the country.
Oxford has an alumni network of over 250,000 individuals, including more than 120 Olympic medalists, 26 Nobel Prize winners, seven poets laureate, and over 30 modern world leaders (including Bill Clinton, Aung San Suu Kyi, Indira Ghandi and 26 UK Prime Ministers).
It has a friendly rivalry with Cambridge for the title of best university in the UK and is regularly ranked as being one of the top three universities in the world. Notable Oxford thinkers and scientists include Tim Berners-Lee, Stephen Hawking and Richard Dawkins.