18 Sep 2023
Job Information
Organisation/Company
Institute of Bioorganic Chemistry Polish Academy of Sciences
Department
Doctoral School of the Institutes of the Polish Academy of Sciences at the
Institute of Bioorganic Chemistry, PAS in Poznan
Research Field
Biological sciences » Biology
Chemistry
Researcher Profile
First Stage Researcher (R1)
Country
Poland
Application Deadline
22 Oct 2023 - 23:00 (Europe/Brussels)
Type of Contract
Temporary
Job Status
Full-time
Hours Per Week
40
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Reference Number
27/2023/ICHB/PSD
Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
KEY WORDS: RNA, crystallography, ligands, small molecules, RNA-ligand
complexes, development of therapy of human disorders, neurodegenerative
disorders .
Principal Investigator: dr hab. Agnieszka Kiliszek, Assoc. Prof.
Research topic: Crystallographic analysis of RNA complexes with synthetic
molecules
I. Project description
The aim of the project is crystallographic analysis of complexes of synthetic
ligands with disease-related RNA molecules. The research object is a group of
small compounds recognizing unique pattern of nucleobases, engaged in non-
canonical pairing or located in single stranded regions of RNA molecules.
Target molecules are RNA involved in pathogenesis of large group of
neurodegenerative disorders, such as Huntington's disease, fragile
X-associated tremor ataxia syndrome, myotonic dystrophies and spinocerebellar
ataxias. In the course of the project we will investigate four groups of
synthetic ligands developed by the group of prof. Kazuhiko Nakatani from Osaka
University. Each group recognize different nucleobases and sequences. The main
technique used in the project will be x-ray crystallography (or complementary
methods) supplemented by biochemical evaluation of RNA-ligand complexes. The
structural information derived from the crystallographic models will help to
rationally design and optimise lead compounds, opening new avenues for future
clinical interventions. The final goal of the project is determination of
general structural requirements and guidelines for rational design of small
molecules targeting RNA.
Additional information:
Research and doctoral theses shall be carried out within the OPUS 23 (Project No. 2022/45/B/NZ7/03543), entitled “Crystallographic analysis of RNA-ligand complexes. Towards rational design of lead compounds for development of therapies against neurodegenerative disorders”, funded by National Science Centre
PhD students shall receive a stipend in the gross amount of ca 4300 PLN (3800 PLN net), for the period of 37 months with possible extension
PhD students shall be subject to social insurance, pursuant to article. 6 section 1 passage 7b of the act of October 13th, 1998 on the social insurance system (Journal of Laws of 2019, item 300, 303 and 730).
Requirements
Research Field
Biological sciences » Biology
Education Level
Master Degree or equivalent
Research Field
Chemistry
Education Level
Master Degree or equivalent
Additional Information
Benefits
PhD students shall receive a stipend in the gross amount of ca 4300 PLN (3800
PLN net)
II. Requirements for the candidates:
MSc degree in chemistry, biology or a related field, or fulfilling the conditions stipulated in article 186, section2 of the act of July 20th, 2018 Law on Higher Education and Science (Journal of Laws of 2018, item 1668, as amended).
Basic experience in laboratory work, encompassing molecular biology/biochemistry/chemistry
Knowledge regarding basic issues related to the research topic of the project
Ability to independently solve scientific problems, communicativeness, enthusiasm for experimental work and the ability to work in a team
Very good spoken and written English
Additional attribute will be some experience in bio-crystallography or crystallography of small molecules
III. Duties in project:
Planning and conducting experiments within the project, analysis of the results.
Involvement in the preparation of scientific publications.
Review and analysis of scientific articles on topics important for the project development.
Presentation of the results at seminars and conferences.
IV. Required documents :
Application for admission to PDS IPAS along with the consent for processing personal data upon the recruitment procedure and a statement on having acknowledged the regulations of recruitment for PDS IPAS, using form downloaded from
https: // psd-ipan.ichb.pl/wp-
content/uploads/2023/05/ICHBApplicationforadmission100523.docx
Certified copy of the diploma confirming graduation or a certificate confirming graduation (in the case of diplomas issued by foreign higher education schools, diploma stipulated in article 326, section 2, passage 2 or article 327, passage 2 of the act of July 20th, 2018 – Law on Higher Education and Science (Journal of Laws of 2018, item 1668, as amended), entitling to apply for conferment of a doctoral degree in the state in where such a certificate was issued by the relevant higher education school. In the event when the candidate is not in possession of the aforementioned documents, he/she is obliged to submit them prior to admission to PDS IPAS. Additional information on foreign school diplomas are available at:
https: // nawa.gov.pl/en/recognition/recognition-for-academic-purposes/applying-
for-admission-to-doctoral-studies
Scientific CV encompassing track record of previous education and employment, information on involvement in scientific activities (participation in student research groups, attendance at scientific conferences, accomplished internships and training, awarded prizes and distinction) and list of publications.
Cover letter featuring a short description of research interests, achievements and justification for the intention to commence education at the doctoral school.
Certificates or other documents confirming the degree of proficiency in English, if the candidate is in possession of such materials.
Contact details of at least one, previous scientific supervisor or another researcher who is entitled to issue an opinion on the candidate.
V. Applications should be submitted via the eRecruiter portal at
https: // system.erecruiter.pl/FormTemplates/RecruitmentForm.aspx?WebID=17af1be7d1d6405bb63bff5188b7d508
VI. Submission deadline is 22.10.2023.
VII. Criteria for evaluation of candidates:
Candidate's research achievements, pursuant to the grades obtained in the course of studies, scientific publications, awarded scholarships and distinctions resulting from conducting scientific research or student activities or other achievements.
Candidate's scientific and professional experience, pursuant to participation in conferences, workshops, training sessions and internships, implementation of research and commercial projects, involvement in scientific trusts and societies, international and professional mobility, experience in other sectors, including industry.
Candidate's knowledge on the following discipline: biological or chemical sciences.
Knowledge of the subject matter described in the recruitment advertisement.
Eligibility criteria
VIII. The recruitment procedure shall be concluded no latter than
05.12.2023.
IX. The description of the recruitment process is stipulated in the
Regulations of Recruitment for PDS IPAS. Following the recruitment procedure,
the unadmitted candidates shall be informed on the number of points obtained
at both stages.
Incomplete applications will not be considered.
For additional information please contact the Principal Investigator:
dr hab. Agnieszka Kiliszek, Assoc. Prof.
e-mail: [email protected]
Selection process
Information clause:
Pursuant to the stipulations of the regulation (EU) 2016/679 of the
European Parliament and of the Council of 27 April 2016 on the protection of
natural persons with regard to the processing of personal data and on the free
movement of such data, and repealing Directive 95/46/EC (General Data
Protection Regulation), further referred to as GDPR, we hereby inform that:
The Institute of Bioorganic Chemistry, Polish Academy of Sciences, seated
in Noskowskiego St. 12/14, 61-704 Poznan; REGON 000849327, NIP
777-00-02-062 is the administrator of the collected personal data
(further referred to as the Institute).
The Administrator appointed a Data Protection Officer, who can be
contacted in writing, via traditional mail, by sending a letter to the
following address: Z. Noskowskiego St. 12/14, 61-704 Poznan, or by sending
an e-mail to:[email protected].
The personal data of the candidates is processed for the purposes of
fulfilling the tasks of the administrator, associated with conducting the
recruitment procedure for a vacant position.
The legal basis for processing personal data is the Act of 26 June 1974
– The Labor Code, Act of 30 April 2010 on the Polish Academy of Sciences
or the consent of the person whose data shall be subjected to processing.
Additional comments
Your personal data shall be subjected to processing for a period of 3
months upon the date of the decision of the recruitment committee.
Following this period, the data will be irretrievably and effectively
destroyed.
The personal data of the candidates shall not be transferred to any
third country.
The person whose data shall be subjected to processing has the right
to:
request access to his/her personal data, and to amend it or delete it, pursuant to articles 15-17 of GDPR;
limit data processing, in the events stipulated in article 18 of GDPR;
data transferring, pursuant to article 20 of GDPR;
withdraw consent at any moment, without influencing compliance with the law of the processing that was executed prior to consent withdrawal;
file a complaint to the Inspector General for Personal Data Protection.
Providing personal data in the scope stipulated in article 22 (1) of the
Act of 26 June 1974 – The Labor Code is mandatory, whereas providing data in a
broader scope is voluntary and requires consent for its processing.
Work Location(s)
Number of offers available
2
Company/Institute
Institute of Bioorganic Chemistry, PAS
Country
Poland
State/Province
wielkopolska
City
Poznań
Postal Code
61-704
Street
Zygmunta Noskowskiego 12/14
Geofield
Where to apply
Website
https: // system.erecruiter.pl/FormTemplates/RecruitmentForm.aspx?WebID=17af1be7d…
Contact
State/Province
wielkopolska
City
Poznan
Website
https:// www. ibch.poznan.pl
Street
Noskowskiego 12/14
Postal Code
61-704
E-Mail
[email protected]
STATUS: EXPIRED
