Göteborg University

Göteborg University

Doctoral Student In Medical Science - Medical Radiation Sciences, Radiation Biology And Cancer

Sweden

Expired

The University of Gothenburg tackles society's challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

Doctoral position in Medical Science

Project title: Exploiting apoptotic vulnerabilities to enhance breast cancer radiotherapy and anti-cancer immune responses

The Department of Medical Radiation Sciences, is located at the Institute of Clinical Sciences at the Faculty of Medicine at Sahlgrenska Academy, University of Gothenburg.

General information about being a doctoral student at the University of Gothenburg can be found on the university's doctoral student pages https: // medarbetarportalen.gu.se/doktorand/?languageId=100001&skipSSOCheck=true

Duties

The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https: // www. gu.se/en/sahlgrenska-akademin/doctoral-studies

Project: The overall goal of the project is to determine how defects in the apoptotic machinery affect the dynamics and immunogenicity of breast cancer cell death, and how this relates to radiotherapy responses and immune-mediated tumor clearance in vivo. Studies will be performed in cell lines in vitro and in mouse models, as well as ex vivo in patient biopsies. As a PhD-student, you will use flow cytometry to perform functional cell death measurements such as BH3 profiling and Annexin V staining, but also use methods such as western blotting, ELISA, qPCR, and immunohistochemistry.

Radioresistance in relapsed breast cancer poses a significant clinical challenge. Cancer immunotherapy has had great success in recent years, but despite large effects and sometimes cure in some patients, most do not respond to treatment. Combining radiotherapy and immunotherapy is a proposed way to increase treatment effects. We propose that dysfunctions in the apoptotic cell death pathway, specifically caspase deficiency, may influence radiation- induced tumor cell killing and anti-cancer immune responses. Preliminary findings indicate that caspase restriction can be detected using a novel functional assay, potentially predicting treatment responses. This project aims to elucidate the mechanisms underlying this phenotype and explore the therapeutic potential of modulating caspase restriction in breast cancer.

Education at third-cycle level comprises four years of full-time study, and leads to a doctoral degree. As part of your employment as a doctoral student, you may have departmental duties corresponding to up to 20 % of full-time employment, distributed throughout your study period. Departmental duties usually consist of teaching at first- and second-cycle levels, but may also include research and administration.

Eligibility

Education at third-cycle level requires general eligibility and specific eligibility as set out in the general syllabus for the subject.

The general eligibility requirements for education at third-cycle level are: 1. having completed a degree at second-cycle level, or 2. the fulfilment of course requirements totalling at least 240 credits, of which at least 60 credits must be at second-cycle level, or 3. the acquisition of equivalent knowledge in some other way, either in Sweden or abroad.

Specific entry requirements for this subject, according to the general syllabus, are: having completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies.

Assessment criteria

The selection of applicants who are considered to have the ability required to benefit from the study programme and who meet the general and specific eligibility requirements are assessed based on the following documented qualifications: - specific knowledge and skills within the subject area and related research fields - experience of scientific theory and relevant research methodology - scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.

Documented experience of work with molecular biology methods on DNA, RNA and protein levels is of merit. It is also meritorious to have experience in ionizing radiation and radiation biology. Good ability to speak and write in English is desirable.

Employment

Once you have been admitted for education at third-cycle level, you will be employed as a doctoral student at the University of Gothenburg. The provisions for employment as a doctoral student can be found in ordinance SFS 1993:100. Initial employment as a doctoral student may apply for a maximum of one year, and may be renewed by a maximum of two years at a time. A doctoral student may be employed as a doctoral student for a maximum of eight years, but the total period of employment may not be longer than the equivalent of full-time education at third-cycle level for four years.

Location: Sahlgrenska Academy, Institute of Clinical Sciences, Department of Medical Radiation Sciences. Extent: 100%. First day of employment: as agreed.

The University applies a local agreement on salaries for doctoral students.

Contact information

For more information about the project please contact the principal supervisor, Eva Forssell-Aronsson, Professor, Institute of Clinical Sciences, phone: +46703722626, e-mail: [email protected]

Unions

Union representatives at the University of Gothenburg can be found here: https: // www. gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande

Application

You can apply to be admitted for education at third-cycle level via the University of Gothenburg's recruitment portal. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.

You must include the following, in pdf format

  • Personal letter
  • CV
  • Diploma and transcripts showing that you meet with the general entry requirement
  • Proof of completion of English 6 course or the acquired equivalent knowledge through previous studies
  • If your degree is from a university outside of Sweden, make sure that you attach a diploma and full transcripts that makes assessing your degree easier .

    If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.

    For information on what you need to submit in order to fulfill the English language requirement see https: // www. universityadmissions.se/en/entry- requirements/english-language-requirements/

    Applications must be received by: 2024-04-17

    Information for International Applicants

    Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit:

    https: // www. gu.se/en/about-the-university/welcome-services https: // www. movetogothenburg.com/

    The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

    Salaries are set individually at the University.

    In accordance with the National Archives of Sweden's regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

    In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.

    Job details

    Title

    Doctoral Student In Medical Science - Medical Radiation Sciences, Radiation Biology And Cancer

    Employer

    Göteborg University

    Location

    Sweden

    Published

    March 26, 2024

    Application deadline

    April 17, 2024

    Job type

    PhD

    Field

    Biology,Chemistry,Medicine,Physics

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