16 Sep 2023

Job Information

Organisation/Company

CNRS

Department

Institut Camille Jordan

Research Field

Physics

Researcher Profile

First Stage Researcher (R1)

Country

France

Application Deadline

6 Oct 2023 - 23:59 (UTC)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

35

Offer Starting Date

9 Oct 2023

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The successful PhD student will work in the Institut Camille Jordan (UMR5208), a mathematics laboratory headed by Véronique MAUME-DESCHAMPS (270 staff), and the LBBE laboratory (UMR5558), specialising in biometry and evolutionary biology, headed by Fabrice VAVRE (216 staff). The 2 laboratories are located in Villeurbanne on the La Doua campus of the Université Claude Bernard Lyon 1. This thesis is part of the ANR THERMADAPT project and will be supervised by Philippe MALBOS, the project's scientific manager, and Céline Brochier-Armanet from the LBBE.

Thesis subject : Analysis of the signal contained in the 3D structures of proteins using topological persistence This thesis lies at the interface between evolutionary biology and algorithmic topology. It aims to optimise and extend topological data analysis methods, such as persistent homology, to study the information contained in the 3D structures of proteins. This thesis will tackle the problem of constructing the simplicial complex of a 3D protein structure using topological filtering that takes into account the physicochemical properties of amino acids and secondary structures. It will also apply multivariate and weighted persistent homology techniques to this context and refine the calculation of Wasserstein distance with probability measures on the barcodes of 3D structures, taking into account substitution mechanisms within sequences and protein sequence evolution models.

Requirements

Research Field

Physics

Education Level

PhD or equivalent

Languages

FRENCH

Level

Basic

Research Field

Physics

Years of Research Experience

None

Additional Information

Website for additional job details

https: // emploi.cnrs.fr/Offres/Doctorant/UMR5208-CHRLES-009/Default.aspx

Work Location(s)

Number of offers available

1

Company/Institute

Institut Camille Jordan

Country

France

City

VILLEURBANNE

Where to apply

Website

https: // emploi.cnrs.fr/Candidat/Offre/UMR5208-CHRLES-009/Candidater.aspx

Contact

City

VILLEURBANNE

Website

https:// math.univ-lyon1.fr

STATUS: EXPIRED